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Home News

CRISPR License Framework to Encourage Innovation

2. September 2019
in News, Pharmaceuticals
Merck Receives First U.S. Patent for Improved CRISPR Genome-Editing Method

Picture: Merck

Mer­ck, a sci­ence and tech­nol­o­gy com­pa­ny, and the Broad Insti­tute of MIT and Har­vard (Boston, Mass­a­chu­setts) announced an agree­ment to offer non-exclu­sive licens­es to CRISPR intel­lec­tu­al prop­er­ty (IP) under their respec­tive con­trol for use in com­mer­cial research and prod­uct development.

“Togeth­er with the Broad Insti­tute, we are sim­pli­fy­ing the path to licens­ing CRISPR tech­nol­o­gy, which will make it more wide­ly avail­able to the glob­al research and dis­cov­ery com­mu­ni­ty,” said Udit Batra, mem­ber of the Mer­ck Exec­u­tive Board and CEO Life Sci­ence. “Through this agree­ment, we will make it eas­i­er for our cus­tomers to be suc­cess­ful in their research that short­ens drug devel­op­ment time­lines for pre­vi­ous­ly untreat­able diseases.”

Broad Insti­tute and Mer­ck share the goal of enabling all enti­ties to apply the tech­nol­o­gy with a wider range of CRISPR tools. To stream­line access for sci­en­tists, Broad Insti­tute will offer licens­es to Merck’s and Broad Institute’s CRISPR IP port­fo­lios to poten­tial licensees for inter­nal research use and for com­mer­cial research tools and kits. Under the agree­ment, com­pa­nies apply­ing CRISPR in their research and devel­op­ment activ­i­ties can license both sets of IP through Broad Insti­tute. The frame­work is designed to allow oth­er key patent hold­ers to par­tic­i­pate in the future — either through this frame­work or via a third-par­ty patent pool or col­lab­o­ra­tion — to fur­ther stream­line non-exclu­sive access to key CRISPR technology.

“We believe that key CRISPR patent hold­ers should come togeth­er to sim­pli­fy and open up access, and this agree­ment is anoth­er exam­ple of a part­ner­ship that helps max­i­mize and stream­line access to these impor­tant sci­en­tif­ic tools,” said Issi Rozen, Chief Busi­ness Offi­cer of the Broad Insti­tute. “Broad Insti­tute already licens­es CRISPR non-exclu­sive­ly for all appli­ca­tions, with the excep­tion of human ther­a­peu­tics. We are active­ly work­ing to ensure the widest and sim­plest pos­si­ble access to key CRISPR intel­lec­tu­al property.”

The insti­tu­tions worked togeth­er to devel­op a frame­work that (i) con­tin­ues to pro­vide non-exclu­sive access to Broad-con­trolled IP co-owned with its col­lab­o­ra­tors (includ­ing Har­vard Uni­ver­si­ty, the Mass­a­chu­setts Insti­tute of Tech­nol­o­gy, New York Genome Cen­ter, New York Uni­ver­si­ty, The Rock­e­feller Uni­ver­si­ty, the Uni­ver­si­ty of Iowa Research Foun­da­tion, The Uni­ver­si­ty of Tokyo, the White­head Insti­tute for Bio­med­ical Research and oth­ers) and (ii) pro­vides non-exclu­sive access to IP from Mer­ck, with cer­tain lim­i­ta­tions spe­cif­ic to the Mer­ck IP for cre­ation of rodent models.

Fea­tures of the licens­ing framework:

  • Merck’s IP for CRISPR tech­nol­o­gy, offered under the Sig­ma-Aldrich port­fo­lio brand, will become avail­able roy­al­ty-free to non-prof­it aca­d­e­m­ic insti­tu­tions, non-prof­it busi­ness com­mu­ni­ties and gov­ern­men­tal agen­cies for their inter­nal research, con­sis­tent with the Broad Institute’s long-stand­ing prac­tice and requirements.
  • Licens­es fol­low Broad Institute’s and Merck’s eth­i­cal licens­ing con­sid­er­a­tions, which exclude cer­tain CRISPR tech­nol­o­gy appli­ca­tions, such as any for clin­i­cal human germline editing.
  • Each orga­ni­za­tion can con­tin­ue offer­ing licens­es inde­pen­dent­ly, out­side of this framework.
  • In addi­tion to IP from Broad Insti­tute and Mer­ck, this licens­ing frame­work includes cer­tain Broad IP co-owned with mul­ti­ple oth­er insti­tu­tions: Har­vard Uni­ver­si­ty, the Mass­a­chu­setts Insti­tute of Tech­nol­o­gy, The Rock­e­feller Uni­ver­si­ty, the Uni­ver­si­ty of Iowa Research Foun­da­tion, the Uni­ver­si­ty of Tokyo, the White­head Insti­tute for Bio­med­ical Research and others.

Broad Insti­tute and Mer­ck have each devel­oped guide­lines that sup­port research with genome edit­ing under care­ful con­sid­er­a­tion of eth­i­cal and legal stan­dards. The Broad Insti­tute out­lines “insti­tu­tion­al poli­cies on IP licens­ing” on its web­site. Mer­ck has estab­lished an inde­pen­dent, exter­nal Bioethics Advi­so­ry Pan­el to pro­vide guid­ance for research in which its busi­ness­es are involved, includ­ing research on or using genome edit­ing, and has defined a clear oper­a­tional posi­tion tak­ing into account sci­en­tif­ic and soci­etal issues to inform promis­ing ther­a­peu­tic approach­es for use in research and applications.

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