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Electrochemical sensors for early detection of kidney disease

11. February 2022
in News, Pharmaceuticals, Processing Technologies

The kid­neys are vital organs that clean the blood and influ­ence many bod­i­ly func­tions. In many kid­ney dis­eases, there is ini­tial­ly nei­ther pain nor symp­toms. Often, it is only as a result of a ran­dom exam­i­na­tion that pro­teins or only micro­scop­i­cal­ly vis­i­ble traces of blood in the urine indi­cate dam­age to the kidney.

The Brazil­ian mate­ri­als sci­en­tist Dr. Maria Rita Orte­ga Vega would like to devel­op a com­plete­ly new method for the ear­ly detec­tion of kid­ney dis­ease at the Tech­ni­cal Uni­ver­si­ty of Dres­den. To this end, she is col­lab­o­rat­ing with host Prof. Ste­fan Kaskel and his team as part of a Hum­boldt research stay. Kaskel is a pro­fes­sor of inor­gan­ic chem­istry and is par­tic­u­lar­ly involved in research into porous mate­ri­als, includ­ing for the ener­gy tran­si­tion and for envi­ron­men­tal tech­nolo­gies. How­ev­er, Dr. Orte­ga Vega wants to use these mate­ri­als in her project “Nanos­truc­tured tran­si­tion met­al-based elec­tro­chem­i­cal sen­sor for sali­vary urea detec­tion for kid­ney fail­ure diag­nos­tics” to detect and quan­ti­fy urea in sali­va using elec­tro­chem­i­cal techniques.

“The pres­ence and amount of urea in sali­va can be an indi­ca­tor of kid­ney prob­lems. With such a sen­sor, patients and physi­cians can obtain reli­able results quick­ly and with­out blood test­ing. For patients who are already in the chron­ic stage of the dis­ease, this tech­nol­o­gy can help eval­u­ate the per­for­mance of the dial­y­sis process. We expect to joint­ly devel­op a spe­cif­ic and sen­si­tive mate­r­i­al for this application.”

- Maria Rita Orte­ga Vega

“I am delight­ed that we have been able to attract Ms. Orte­ga, a tal­ent­ed young sci­en­tist who is an excel­lent fit for our team, to TU Dres­den. Her inno­v­a­tive research into new top­ics in biosen­sorics will cer­tain­ly ben­e­fit deci­sive­ly from the exper­tise at Dres­den as a cen­ter of excel­lence,” Prof. Kaskel is certain.
As a Hen­ri­ette Heart Scout of the Alexan­der von Hum­boldt Foun­da­tion, he has the oppor­tu­ni­ty to iden­ti­fy three excel­lent and high­ly sought-after young sci­en­tists from abroad, to pro­pose them for a Hum­boldt Research Fel­low­ship and to bring them to the TU Dres­den. Maria Rita Orte­ga Vega is the first fel­low Kaskel was able to recruit for his team in this way.

“I liked the team’s lev­el of work: there are many promis­ing devel­op­ments here with great oppor­tu­ni­ties for tech­nol­o­gy trans­fer and applic­a­bil­i­ty. That’s very impor­tant to me: doing sci­ence that can have an impact on soci­ety. I con­sid­er sci­ence as a demo­c­ra­t­ic project, so research­ing sys­tems and mate­ri­als that are scal­able to make them acces­si­ble to peo­ple through dif­fer­ent appli­ca­tions and make life eas­i­er, i.e. “mate­ri­al­iz­ing” knowl­edge, is a great moti­va­tion. I also liked the infra­struc­ture, which is very dif­fer­ent from the one in Brazil. TUD has oth­er tech­nolo­gies and equip­ment that I haven’t seen before and I’m look­ing for­ward to learn­ing about them,” Maria Rita says about her moti­va­tion to accept Ste­fan Kaskel’s invi­ta­tion to Dresden.

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